Mark A. Giembycz: search on Z-Library

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1

Choking the breath out of respiratory diseases!

Mark A. Giembycz

Journal:

Trends in Pharmacological Sciences

Year:

2001

Language:

english

File:

PDF, 37 KB

english, 2001

2

Forskolin inhibits leukotriene D4-induced thromboxane B2 release from guinea-pig lung parenchyma

Mark A. Giembycz, Ian W. Rodger

Journal:

Year:

1984

Language:

english

File:

PDF, 66 KB

english, 1984

3

Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells

Smith, Susan J., Brookes-Fazakerley, Steven, Donnelly, Louise E., Barnes, Peter J., Barnette, Mary S., Giembycz, Mark A.

Journal:

American journal of physiology. Lung cellular and molecular physiology

Year:

2003

Language:

english

File:

PDF, 462 KB

english, 2003

4

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 â¢ San Francisco, California - ()] D35. PHOSPHODIESTERASE INHIBITORS AS THERAPEUTICS FOR LUNG DISEASES - Phosphodiesterase 4 Inhibitors Suppress Chemokine Release From Human Airway Epithelial Cells By A Novel, 15-Lipoxygenase-2- And PPARg-Dependent Mechanism

Wilson, Sylvia M., Newton, Robert, Giembycz, Mark

Year:

2012

File:

PDF, 20 KB

2012

5

[American Thoracic Society American Thoracic Society 2011 International Conference, May 13-18, 2011 â¢ Denver Colorado - ()] C21. NEW TARGETS FOR ASTHMA THERAPY - TNFAlpha Reduces Glucocorticoid-Dependent Transcription: Rescue By Long-Acting Beta2-Adrenceptor Agonists And JNK Inhibition

Rider, Christopher F., Giembycz, Mark A., Newton, Robert

Year:

2011

File:

PDF, 19 KB

2011

6

[American Thoracic Society American Thoracic Society 2011 International Conference, May 13-18, 2011 â¢ Denver Colorado - ()] A68. AN ENDOCRINE STUDY OF THE LUNG: GLUCOCORTICOIDS, SEX, AND OTHER HORMONES - Pro-Inflammatory Stimuli Reduce Glucocorticoid-Dependent Transcription: A Form Of Induced Resistance To Glucocorticoids

Rider, Christopher F., King, Elizabeth M., Traves, S L., Holden, Neil S., Proud, David, Giembycz, Mark A., Newton, Robert

Year:

2011

File:

PDF, 19 KB

2011

7

PHOSPHODIESTERASE INHIBITORS: WILL THEY REPLACE THEOPHYLLINE?

Peter J Barnes, Mark Giembycz

Journal:

Clinical & Experimental Allergy

Year:

1993

Language:

english

File:

PDF, 91 KB

english, 1993

8

Selective Phosphodiesterase Inhibitors in the Therapy of Asthma

Gordon Dent,Dr Mark A. Giembycz

Journal:

Year:

1995

Language:

english

File:

PDF, 1.41 MB

english, 1995

9

Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers

Curtis, Michael J, Alexander, Steve, Cirino, Giuseppe, Docherty, James R, George, Christopher H, Giembycz, Mark A, Hoyer, Daniel, Insel, Paul A, Izzo, Angelo A, Ji, Yong, MacEwan, David J, Sobey, Chri

Journal:

British Journal of Pharmacology

Year:

2018

Language:

english

File:

PDF, 662 KB

english, 2018

10

Putative substrates for cyclic nucleotide-dependent protein kinases and the control of airway smooth muscle tone

Mark A. Giembycz, David Raeburn

Journal:

Autonomic and Autacoid Pharmacology

Year:

1991

Language:

english

File:

PDF, 2.95 MB

english, 1991

11

Characterization of phosphodiesterase 4 in guinea-pig macrophages: multiple activities, association states and sensitivity to selective inhibitors

John J Kelly, Peter J Barnes, Mark A Giembycz

Journal:

British Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 463 KB

english, 1998

12

p38 MAP kinase and MKK-1 co-operate in the generation of GM-CSF from LPS-stimulated human monocytes by an NF-κB-independent mechanism

Koremu K Meja, Paul M Seldon, Yasuyuki Nasuhara, Kazuhiro Ito, Peter J Barnes, Mark A Lindsay, Mark A Giembycz

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 270 KB

english, 2000

13

Cyclic AMP-elevating agents prolong or inhibit eosinophil survival depending on prior exposure to GM-CSF

Matthew P. Hallsworth, Mark A. Giembycz, Peter J. Barnes, Tak H. Lee

Journal:

British Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.69 MB

english, 1996

14

Phosphodiesterase 4 inhibitors delay human eosinophil and neutrophil apoptosis in the absence and presence of salbutamol

Jouni Parkkonen, Hannele Hasala, Eeva Moilanen, Mark A. Giembycz, Hannu Kankaanranta

Journal:

Pulmonary Pharmacology & Therapeutics

Year:

2008

Language:

english

File:

PDF, 251 KB

english, 2008

15

Leukotriene D4 receptors are not negatively coupled to adenylyl cyclase in guinea-pig lung parenchyma

Mark A. Giembycz, Jack Diamond, Ian W. Rodger

Journal:

British Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.94 MB

english, 1993

16

Ketotifen Induces Primary Necrosis of Human Eosinophils

Hasela, Hannele, Malm-Erjefält, Monika, Erjefält, Jonas, Giembycz, Mark A., Zhang, Xianzhi, Moilanen, Eeva, Kankaanranta, Hannu

Journal:

Journal of Ocular Pharmacology and Therapeutics

Year:

2005

Language:

english

File:

PDF, 362 KB

english, 2005

17

An estimation of β2-adrenoceptor reserve on human bronchial smooth muscle for some sympathomimetic bronchodilators

Mark A Giembycz

Journal:

British Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 416 KB

english, 2009

18

E-Ring 8-isoprostanes inhibit ACh release from parasympathetic nerves innervating guinea-pig trachea through agonism of prostanoid receptors of the EP3-subtype

Deborah L Clarke, Mark A Giembycz, Hema J Patel, Maria G Belvisi

Journal:

British Journal of Pharmacology

Year:

2004

Language:

english

File:

PDF, 263 KB

english, 2004

19

Release of granulocyte-macrophage colony stimulating factor by human cultured airway smooth muscle cells: suppression by dexamethasone

Michael A. Saunders, Jane A. Mitchell, Paul M. Seldon, Magdi H. Yacoub, Peter J. Barnes, Mark A. Giembycz, Maria G. Belvisi

Journal:

British Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 279 KB

english, 1997

20

Partial characterization of cyclic AMP-dependent protein kinases in guinea-pig lung employing the synthetic heptapeptide substrate, Kemptide: In vitro sensitivity of the soluble enzyme to isoprenaline, forskolin, methacholine and leukotriene D4

Mark A. Giembycz, Jack Diamond

Journal:

Biochemical Pharmacology

Year:

1990

Language:

english

File:

PDF, 1.79 MB

english, 1990

21

First-generation antihistamines diphenhydramine and chlorpheniramine reverse cytokine-afforded eosinophil survival by enhancing apoptosis

Hasala, Hannele, Moilanen, Eeva, Janka-Junttila, Mirkka, Giembycz, Mark A., Kankaanranta, Hannu

Journal:

Allergy and Asthma Proceedings

Year:

2007

Language:

english

File:

PDF, 1.38 MB

english, 2007

22

[American Thoracic Society American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans - ()] A65. GENE EXPRESSION, PHENOTYPE, AND FUNCTION IN AIRWAY SMOOTH MUSCLE: NEW INSIGHTS - Signalling Pathways Involved In ²2-adrenoceptor Agonist Induced Relaxation Of Airway Smooth Muscle

Clarke, Deborah L., Laroumanie, Fanny, Buckley, James, Giembycz, Mark, Birrell, Mark A., Belvisi, Maria G.

Year:

2010

Language:

english

File:

PDF, 21 KB

english, 2010

23

Analysis of the Indacaterol-Regulated Transcriptome in Human Airway Epithelial Cells Implicates Gene Expression Changes in the Adverse and Therapeutic Effects of β 2 -Adrenoceptor Agonists

Yan, Dong, Hamed, Omar, Joshi, Taruna, Mostafa, Mahmoud M., Jamieson, Kyla C., Joshi, Radhika, Newton, Robert, Giembycz, Mark A.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2018

Language:

english

File:

PDF, 11.88 MB

english, 2018

24

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 â¢ San Francisco, California - ()] D73. RECEPTOR INPUT OF AIRWAY NETWORKING - Synergistic Enhancement Of Glucocorticoid-Dependent Transcription By Epinephrine In The Presence Of Dexamethasone Is Predominantly Mediated Through The Â²2-Adrenoceptor

Gaunt, David D., Giembycz, Mark, Johnson, David W., Newton, Robert

Year:

2012

File:

PDF, 18 KB

2012

25

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 â¢ San Francisco, California - ()] D35. PHOSPHODIESTERASE INHIBITORS AS THERAPEUTICS FOR LUNG DISEASES - Phosphodiesterase 4 Inhibitors Enhance Glucocorticoid-Dependent Gene Transcription In Human Airway Epithelial Cells: A Mechanism For The Clinical Efficacy Of Roflumilast In Severe Chronic Obstructive Pulmonary Disease

Moodley, Thunicia, Wilson, Sylvia, Joshi, Taruna, Sharma, Pawan, Rider, Christopher F., Newton, Robert, Giembycz, Mark

Year:

2012

File:

PDF, 20 KB

2012

26

Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan-stimulated respiratory burst by ‘type IV’-selective PDE inhibitors

Gordon Dent, Mark A. Giembycz, Klaus F. Rabe, Peter J. Barnes

Journal:

British Journal of Pharmacology

Year:

1991

Language:

english

File:

PDF, 1.48 MB

english, 1991

27

Cytokine-Induced Loss of Glucocorticoid Function: Effect of Kinase Inhibitors, Long-Acting β2-Adrenoceptor Agonist and Glucocorticoid Receptor Ligands

Rider, Christopher F., Shah, Suharsh, Miller-Larsson, Anna, Giembycz, Mark A., Newton, Robert, Wang, Zhengqi

Journal:

Year:

2015

Language:

english

File:

PDF, 75 KB

english, 2015

28

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 â¢ San Francisco, California - ()] D35. PHOSPHODIESTERASE INHIBITORS AS THERAPEUTICS FOR LUNG DISEASES - GS-5759, A Novel Bi-Functional Phosphodiesterase 4 Inhibitor And Long-Acting Â²2-Adrenoceptor Agonist, Inhibits CXCL9 And CXCL10 Release From Human Airway Epithelial Cells

Wilson, Sylvia M., Joshi, Taruna, Tannheimer, Stacey L., Wright, Clifford D., Salmon, Michael, Newton, Robert, Giembycz, Mark A.

Year:

2012

File:

PDF, 21 KB

2012

29

Prostaglandin E2 suppression of acetylcholine release from parasympathetic nerves innervating guinea-pig trachea by interacting with prostanoid receptors of the EP3-subtype

Lucia Spicuzza, Mark A. Giembycz, Peter J. Barnes, Maria G. Belvisi

Journal:

British Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 320 KB

english, 1998

30

Characterization of the prostanoid receptor(s) on human blood monocytes at which prostaglandin E2 inhibits lipopolysaccharide-induced tumour necrosis factor-α generation

Koremu K. Meja, Peter J. Barnes, Mark A. Giembycz

Journal:

British Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 421 KB

english, 1997

31

Role of arachidonic acid in leukotriene B4-induced guinea-pig eosinophil homotypic aggregation

Mauro M. Teixeira, Mark A. Lindsay, Mark A. Giembycz, Paul G. Hellewell

Journal:

European Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 162 KB

english, 1999

32

Rolipram, salbutamol and prostaglandin E2 suppress TNFα release from human monocytes by activating Type II cAMP-dependent protein kinase

Paul M. Seldon, Koremu K. Meja, Mark A. Giembycz

Journal:

Pulmonary Pharmacology & Therapeutics

Year:

2005

Language:

english

File:

PDF, 218 KB

english, 2005

33

Retinoids offer hope for the treatment of emphysema

Journal:

Trends in Pharmacological Sciences

Year:

2000

Language:

english

File:

PDF, 41 KB

english, 2000

34

Delayed eosinophil apoptosis in asthma

Kankaanranta, Hannu, Lindsay, Mark A., Giembycz, Mark A., Zhang, Xianzhi, Moilanen, Eeva, Barnes, Peter J.

Journal:

Journal of Allergy and Clinical Immunology

Year:

2000

Language:

english

File:

PDF, 78 KB

english, 2000

35

Phosphodiesterase 4 Inhibitors and the Treatment of Asthma

Dr Mark A. Giembycz

Journal:

Year:

2000

Language:

english

File:

PDF, 312 KB

english, 2000

36

Salmeterol is a competitive antagonist at β-adrenoceptors mediating inhibition of respiratory burst in guinea-pig eosinophils

Klaus F. Rabe, Mark A. Giembycz, Gordon Dent, Rosie S. Perkins, Pat Evans, Peter J. Barnes

Journal:

European Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 411 KB

english, 1993

37

PDE4D-deficient mice knock the breath out of asthma

Journal:

Trends in Pharmacological Sciences

Year:

2000

Language:

english

File:

PDF, 53 KB

english, 2000

38

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California - ()] C98. NOVEL AIRWAY EPITHELIAL BARRIER AND IMMUNE RESPONSES - Novel Anti-Inflammatory Mechanisms Of Corticosteroid/Long-Acting ²2-Adrenoceptor Agonist Combination Treatment In Pulmonary Epithelial Cells: Roles For Regulator Of G-Protein Signalling (RGS) 2

Holden, Neil S., Rider, Christopher F., Kaur, Manminder, George, Tresa, Leigh, Richard, Johnson, Malcolm, Giembycz, Mark A., Newton, Robert

Year:

2012

Language:

english

File:

PDF, 19 KB

english, 2012

39

Prostanoid receptors of the EP 4 -subtype mediate gene expression changes in human airway epithelial cells with potential anti-inflammatory activity

Joshi, Radhika, Hamed, Omar, Yan, Dong, Michi, Aubrey N, Mostafa, Mahmoud M, Wiehler, Shahina, Newton, Robert, Giembycz, Mark A.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2020

File:

PDF, 1.32 MB

2020

40

Extracellular signal-regulated kinase 1/2 control Ca2+-independent force development in histamine-stimulated bovine tracheal smooth muscle

Andrea Koch, Yasuyuki Nasuhara, Peter J Barnes, Mark A Lindsay, Mark A Giembycz

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 263 KB

english, 2000

41

Conquering airway inflammation in the 21st century

Duncan F. Rogers, Mark A. Giembycz

Journal:

Drug Discovery Today

Year:

1998

Language:

english

File:

PDF, 291 KB

english, 1998

42

Could isoenzyme-selective phosphodiesterase inhibitors render bronchodilator therapy redundant in the treatment of bronchial asthma?

Mark A. Giembycz

Journal:

Biochemical Pharmacology

Year:

1992

Language:

english

File:

PDF, 1.32 MB

english, 1992

43

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California - ()] D73. RECEPTOR INPUT OF AIRWAY NETWORKING - TNF±-Induced Glucocorticoid Resistance: Inhibition Of Inflammatory Signalling And The Effect On Full And Partial GR Agonists

Rider, Christopher F., Shah, Suharsh, Gaunt, David D., Miller-Larsson, Anna, Johnson, Malcolm W., Giembycz, Mark A., Newton, Robert

Year:

2012

Language:

english

File:

PDF, 21 KB

english, 2012

44

Phosphodiesterase 4 in macrophages: relationship between cAMP accumulation, suppression of cAMP hydrolysis and inhibition of [ 3 H] R -(—)-rolipram binding by selective inhibitors

KELLY, John J, BARNES, Peter J, GIEMBYCZ, Mark A

Journal:

Biochemical Journal

Year:

1996

Language:

english

File:

PDF, 943 KB

english, 1996

45

A bronchoprotective role for Rgs2 in a murine model of lipopolysaccharide-induced airways inflammation

George, Tresa, Chakraborty, Mainak, Giembycz, Mark A., Newton, Robert

Journal:

Allergy, Asthma & Clinical Immunology

Year:

2018

Language:

english

File:

PDF, 2.34 MB

english, 2018

46

Pharmacological strategies for improving the efficacy and therapeutic ratio of glucocorticoids in inflammatory lung diseases

Robert Newton, Richard Leigh, Mark A. Giembycz

Journal:

Pharmacology & Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.55 MB

english, 2010

47

Salbutamol delays human eosinophil apoptosis via a cAMP-dependent mechanism

Hannu Kankaanranta, Jouni Parkkonen, Pinja Ilmarinen-Salo, Mark A. Giembycz, Eeva Moilanen

Journal:

Pulmonary Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 535 KB

english, 2011

48

Hydrogen Peroxide Reverses IL-5 Afforded Eosinophil Survival and Promotes Constitutive Human Eosinophil Apoptosis

Kankaanranta, Hannu, Giembycz, Mark A., Barnes, Peter J., Haddad, El-Bdaoui, Saarelainen, Seppo, Zhang, Xianzhi, Moilanen, Eeva, Lindsay, Mark A.

Journal:

International Archives of Allergy and Immunology

Year:

2002

Language:

english

File:

PDF, 274 KB

english, 2002

49

Bidirectional crosstalk via IL-6, PGE 2 and PGD 2 between murine myofibroblasts and alternatively activated macrophages enhances anti-inflammatory phenotype in both cells

Fernando, Maria R, Giembycz, Mark A, McKay, Derek M

Journal:

British Journal of Pharmacology

Year:

2016

Language:

english

File:

PDF, 1.14 MB

english, 2016

50

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California - ()] D35. PHOSPHODIESTERASE INHIBITORS AS THERAPEUTICS FOR LUNG DISEASES - GS-5759, A Novel Bi-Functional Phosphodiesterase 4 Inhibitor And Long-Acting ²2-Adrenoceptor Agonist, Augments GRE-Dependent Transcription In Human Airway Epithelial Cells

Joshi, Taruna, Wilson, Sylvia M., Wright, Clifford D., Tannheimer, Stacey L., Salmon, Michael, Newton, Robert, Giembycz, Mark A.

Year:

2012

Language:

english

File:

PDF, 20 KB

english, 2012

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